Comparison of efficacy and safety of Levosulpiride and Domperidone in functional dyspepsia

Copyright  2015 irjpbs Objective: To compare the efficacy and safety of levosulpiride with dompenidone in patients with functional dyspepsia Material & Method: It was a prospective, double blind, randomized study conducted on 182 patients in two groups of 91 each. Group A: levosulpiride 25mg TID daily orally for 4 weeks, Group B: Domperidone 10mg TID daily orally for 4 weeks. Individual symptoms (Abdominal pain, discomfort, nausea, vomiting, anorexia, post prandial bloating, belching, regurgitation, heart burn & abdominal fullness) and severity of symptoms were assessed by predetermined grading system at baseline (0), 2, 4 & 8 weeks i.e. 1st, 2nd, 3rd, & 4th visit respectively. Results: Among 182 patients 171 completed the study most of the cases were in 20 to 40 years (69%) with male preponderance (71.35%). Highly significant (p>0.001)improvement in symptoms like post prandial bloating (82%) and abdominal pain (81.63%) were noticed with levosulpiride as compared to domperidone [post prandial bloating (57%), abdominal pain (45%)]. Both the treatment groups were comparable for other symptoms. Conclusion: levosupiride is more effective but less safe than domperidone in FD.